Man Unconscious for 3 Hours in Semen... Ultra-Simple Male Contraceptive Pill to Be Released
Sperm That 'Faint' Within 30 Minutes of Ingestion
Developed by Researchers at Weill Cornell Medicine, USA
Few Side Effects... "Cannot Prevent STDs"
A male contraceptive pill that stops sperm activity for about 3 hours when taken as needed has been developed.
On the 14th (local time), according to the British BBC, a research team led by Jochen Buck from the Department of Pharmacology at Weill Cornell Medicine in the United States announced research results showing that sperm activity can be temporarily halted only when necessary through medication. The study was published in the international academic journal Nature Communications.
Unlike female contraceptives, the biggest advantage of the new drug is that it does not affect hormones. The research team explained, "It will not cause side effects such as deficiency of the male hormone testosterone."
The switch that activates sperm motility is a cell signaling protein called soluble adenylyl cyclase (sAC), which plays a role in producing cellular energy.
The drug developed by the research team, 'TDI-11861,' works by inhibiting or blocking sAC to prevent sperm movement. It is reported that the drug takes effect within 30 minutes of ingestion.
The researchers administered the contraceptive to mice and observed sperm movement before, during, and after mating.
As a result, the contraceptive effect that stops sperm movement was 100% effective for 2 hours and 91% effective up to 3 hours. After 24 hours, the contraceptive effect disappeared, allowing normal reproductive activity.
No significant side effects were found in experiments where the drug was administered for 6 weeks.
Melanie Balbach, a doctor at Weill Cornell Medicine in New York and one of the researchers, said, "It is expected to become a more convenient contraceptive pill that does not leave harmful effects or damage on the body and can easily return to the pre-ingestion state," adding, "It will also help men plan for childbirth."
Alan Pease, a professor of male medicine at the University of Sheffield in the UK, said, "The development of a male contraceptive pill is essential. Although there have been many studies on male contraceptives (such as blocking proteins on the surface of sperm), none have yet been released to the market," expressing hope that "if the same efficacy observed in animal experiments applies to humans, it will be the male contraceptive method humanity has been seeking."
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Meanwhile, another expert added, "The newly developed contraceptive will not prevent sexually transmitted diseases," emphasizing that "condom use remains important and necessary."
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