Gangdong Kyung Hee University Hospital Recruiting Participants for Clinical Study on Radiation Therapy for Mild Dementia Treatment

Exterior view of Gangdong Kyung Hee University Hospital.

[Asia Economy Reporter Lee Gwan-joo] On the 30th, the team of Professor Jeong Won-gyu from the Department of Radiation Oncology and Professor Lee Hak-young from the Department of Neurology at Gangdong Kyung Hee University Hospital announced the recruitment of participants for a clinical study aimed at evaluating the safety and observing the efficacy of low-dose whole-brain radiation therapy in patients with mild Alzheimer's dementia.

This clinical study targets individuals who have been diagnosed with mild Alzheimer's dementia and have maintained stable dementia medication treatment for more than three months, are aged 60 to 85 with mild dementia, have a caregiver capable of providing information on the participant's overall condition, cognitive function, and functional changes, and have confirmed amyloid brain accumulation on amyloid PET scans.

The clinical study will proceed in the following order: screening tests to confirm the diagnosis of mild Alzheimer's dementia, random assignment (experimental group and control group), radiation therapy, and monitoring of cognitive changes and adverse reactions. A total of 30 participants will be recruited, and the total study period will involve approximately 13 visits after the participant's first visit. Participants will visit the hospital for one year to assess cognitive improvement effects and monitor adverse reactions.

Generally, during radiation therapy for brain tumors or brain metastases, symptoms such as headache, nausea, vomiting, fatigue, loss of appetite, skin discoloration, and hair loss may occur. However, the radiation dose used in this study is within 5% of the dose used for metastatic brain cancer treatment, so side effects are expected to be minimal. If unexpected nonspecific symptoms occur, appropriate treatment will be provided in consultation with the researchers. Participants will receive radiological examination results, medical fees, and transportation expenses.

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