'High-Intensity Aerobic Exercise' Suppresses Cancer Cell Proliferation... Yeungnam University Research Team Identifies Skeletal Muscle-Derived Cancer Suppressor Factor

Utilization Possible in Exercise Program Development, New Drug Candidate Discovery, and Clinical Trials

Professor Ji Hyun-seok, Department of Physical Education, Yeungnam University.

[Asia Economy Yeongnam Reporting Headquarters Reporter Jeonggu Yeo] Professor Ji Hyun-seok's research team from the Department of Physical Education at Yeungnam University has attracted attention by presenting a study showing that high-intensity aerobic exercise suppresses cancer cell proliferation.

Through animal experiments, Professor Ji's research team divided subjects into four groups: ▲healthy group without exercise ▲healthy group with high-intensity aerobic exercise ▲cancer group without exercise ▲cancer group with high-intensity aerobic exercise. They conducted experiments to investigate how high-intensity aerobic exercise, reaching up to 90% of maximum heart rate, effectively inhibits the proliferation of colon cancer cells.

The research team analyzed the muscle gene expression status of these four groups and identified four cancer-suppressing factors derived from skeletal muscle regulated by high-intensity aerobic exercise. They confirmed that regulating the expression of these cancer-suppressing factors can inhibit colon cancer cell proliferation by up to 20%.

Professor Ji Hyun-seok stated, “This research result can serve as an opportunity to shift awareness regarding the habitual practice of exercise, the necessity of optimal exercise, and its effects,” adding, “The skeletal muscle-derived cancer-suppressing factors discovered this time could also be utilized in developing exercise programs, discovering candidate substances for new drug development, and clinical trials.”

This study involved Professor Ji Hyun-seok of Yeungnam University as the first author and corresponding author, and Professor Kim Yoo-sik from the Department of Biological Chemical Engineering at KAIST as a corresponding author. The research results were published in the prestigious international journal Frontiers in Molecular Biosciences.

This content was produced with the assistance of AI translation services.