"Preventing Alzheimer's with Treadmill Exercise" Research Paper by Prof. Joon-Yong Cho's Team at Korea National Sport University Draws Attention
[Asia Economy Reporter Donghoon Jeong] The Exercise Biochemistry Laboratory at Korea National Sport University has attracted attention by publishing a paper that elucidates the effects of treadmill exercise on animals with Alzheimer's disease. The results of this study were published in the internationally renowned journal in the field of molecular neurobiology, Molecular Neurobiology.
According to the paper, with the rapid aging era due to advances in medical technology, the number of patients with the neurodegenerative disease Alzheimer's disease has increased, but there is no clear solution.
Iron that excessively accumulates in the brain due to aging reduces the Furin protein, increasing Amyloid-beta (Aβ), a representative gene of Alzheimer's disease. In addition, the excess iron induces the Fenton reaction, increasing oxidative stress in cells and eventually leading to neuronal cell death.
The research team at the Exercise Biochemistry Laboratory of Korea National Sport University recognized the importance of iron metabolism regulated in the brain of Alzheimer's disease and aimed to analyze the effects of physical activity (exercise). As a result, physical activity (exercise) regulated iron to prevent excessive accumulation, and through the increase of Furin protein, it was involved in reducing Amyloid-beta, thereby alleviating neuronal cell death.
Professor Junyong Cho explained, "Appropriate physical activity can maintain iron metabolic homeostasis in the brain without costly drugs or invasive treatments," adding, "Ultimately, it can be seen as having an antioxidant defense effect because it reduces lipid peroxidation products. This is expected to prevent or delay Alzheimer's disease."
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Professor Cho has conducted research related to neurodegenerative diseases and athletes' performance enhancement at the Exercise Biochemistry Laboratory of Korea National Sport University, publishing numerous SCI and KCI papers, and was awarded the U.S. President's Volunteer Service Award (2019) in education and research fields.
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