Professor at Jeonnam National University Hospital Cardiovascular Convergence Research Center Receives Academic Award from Korean Society of Hypertension

[Asia Economy Honam Reporting Headquarters Reporter Lee Gwan-woo] Research Professor Gi Hae-jin of the Cardiovascular Convergence Research Center at Chonnam National University Hospital received an academic award from the Korean Society of Hypertension.

According to Chonnam National University Hospital on the 5th, Research Professor Gi was honored with the academic award from the Korean Society of Hypertension's journal Clinical Hypertension for his study titled "Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice."

The awarded research was conducted in 2017 with funding from the Korean Society of Hypertension and was published in Clinical Hypertension in 2019.

The study found that PCI34051, a selective inhibitor of histone deacetylase 8 (HDAC8), lowers blood pressure in an angiotensin II-induced hypertensive animal model.

The mechanism of action was identified as a reduction in the expression of angiotensin II receptor type I, inhibition of vascular hypertrophy, improvement of endothelium-dependent vascular relaxation, and suppression of inflammation, all contributing to blood pressure reduction.

To date, 18 types of HDACs have been discovered, and the development of selective inhibitors has been extremely limited. HDAC8 is relatively easier to develop selective inhibitors for, and compared to other HDAC inhibitors, it has fewer side effects and is highly effective not only for hypertension but also for cardiac diseases such as myocardial hypertrophy.

Research Professor Gi stated, "We plan to continue researching selective HDAC8 inhibitors with the goal of developing new treatments for heart diseases."

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