Breakthrough in 4th-Generation Breast Cancer Chemotherapy... Dong-A University Professor Lee Jongho's Team Publishes in International Medical Journal

Joint Research by Chung-Ang University and Semmelweis University in Hungary

Mechanism of Serine Biosynthesis Regulation in Breast Cancer Cells Revealed

Dong-A University (President Lee Haewoo) announced on the 10th that Professor Lee Jongho’s team from the Department of Biomedical Science has published a paper in the online edition of the international medical research journal ‘Experimental & Molecular Medicine’.

This paper, led by Park Suhwan, a Ph.D. candidate in the Cancer Metabolism Laboratory of the Department of Biomedical Science at Dong-A University (first author), and Professor Lee (corresponding author), was also selected as a recommended paper by the Biological Research Information Center (BRIC) ‘Korea’s Proud Researchers (Hanbitsa)’, which highlights outstanding papers by Korean scientists.

‘Experimental & Molecular Medicine’ is a world-class international journal specializing in medical research, boasting an impact factor (IF) of 12.8 and ranking in the top 4.8% in the field of medical research.

This research, supported by the Mid-Career Researcher Program of the Ministry of Science and ICT (National Research Foundation of Korea), was conducted as a joint study with Dr. Park Yunyong and Professor Yoon Sungil of Chung-Ang University, Seoul Asan Medical Center, and a research team from Semmelweis University in Hungary.

In this paper, the research team elucidated the ‘regulatory mechanism of serine biosynthesis in breast cancer cells.’ The title of Professor Lee’s team’s paper is ‘The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.’

The research team discovered that in ‘triple-negative breast cancer,’ which is the most aggressive and has the poorest prognosis among breast cancers, the serine biosynthesis metabolic pathway is activated by the overexpressed adenosine methylation protein ‘RBM15,’ and this plays a crucial role in the growth and survival of triple-negative breast cancer.

Professor Lee stated, “The significance of this study lies in understanding the precise activation mechanism of the serine biosynthesis metabolic pathway, which plays an important role in the growth of cancer cells, and the function of the adenosine methylation protein RBM15. Through this, we have achieved results that provide a fundamental clue for the development of metabolic anticancer agents (fourth-generation anticancer drugs) for triple-negative breast cancer.”

Professor Lee added, “We plan to identify the molecular mechanisms of metabolism, growth, and survival that differentiate cancer cells from normal cells, and to propose new and promising therapeutic targets for the development of cancer metabolism therapeutics.”

Suhwan Park, PhD candidate at Dong-A University (left), and Jongho Lee, professor.

This content was produced with the assistance of AI translation services.