Research Paper on Aibaltinostart Study Published in SCI-Level International Journal

CrystalGenomics Confirms Antihypertensive Efficacy of Ivaltinostat

[Asia Economy Reporter Hyungsoo Park] CrystalGenomics announced on the 2nd that research results suggesting the potential of the epigenetic target inhibitor Ivaltinostat (CG-745) for hypertension treatment have been published in the latest issue of the international journal Hypertension Journal (IF=10.19).

Obesity caused by high-fat intake can induce hypertension through various pathways such as sympathetic nervous system excitation, oxidative stress, inflammation, and hormonal imbalance. Recently, epigenetics has emerged as a pathophysiological mechanism related to obesity-induced hypertension.

The research team administered either a placebo or Ivaltinostat to mice exhibiting hypertension symptoms due to high-fat intake and compared the changes in blood pressure. The results confirmed that the blood pressure of mice treated with Ivaltinostat returned to normal levels.

The team demonstrated that epigenomic changes induced by Ivaltinostat promote the restoration of MsrA (Methionine Sulfoxide Reductase A) reductase expression and facilitate smooth hydrogen sulfide production, thereby enabling hypertension treatment. The human body has a homeostatic mechanism to maintain a certain level of blood pressure. A representative homeostatic mechanism is homocysteine metabolism mediated by MsrA reductase.

Homocysteine metabolism by MsrA reductase induces hydrogen sulfide production. Hydrogen sulfide is an important endogenous gaseous molecule that removes reactive oxygen species and lowers blood pressure. A decrease in MsrA reductase reduces the ability to metabolize homocysteine, leading to increased homocysteine concentration in the body and decreased hydrogen sulfide production.

In fact, homocysteine levels are elevated in patients with vascular diseases such as stroke, heart attack, and peripheral vascular circulation disorders.

The research was conducted through a national research support project. The paper titled “Histone deacetylase inhibition improves high-fat diet-induced hypertension through restoration of the MsrA/hydrogen sulfide axis” can be found in the latest issue of an SCI-level international journal.

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