Dr. Lee Chaesik of Sehwa Hospital Presents Research Findings at the American Society for Reproductive Medicine Annual Congress

Comparative Study of PGT-A and ni-PGT
Suggests Potential of Non-Invasive Genetic Diagnosis

Dr. Lee Chaesik of the Infertility Medicine Research Institute at Sehwa Hospital in Busan presented his research findings at the '2025 Annual Congress of the American Society for Reproductive Medicine (ASRM)' held in San Antonio, Texas, USA, on October 28 (local time). His presentation was titled 'Comparative Analysis of PGT-A and ni-PGT: Reliability Assessment of PGT-A Results.'

This study compared and analyzed the concordance of results and clinical applicability between the conventional invasive preimplantation genetic testing for aneuploidy (PGT-A), which checks for chromosomal abnormalities before embryo transfer during in vitro fertilization (IVF), and the non-invasive preimplantation genetic testing (ni-PGT), which does not harm the embryo.

The Infertility Medicine Research Institute at Sehwa Hospital conducted a retrospective analysis of data from cases in which both PGT-A and ni-PGT were performed over the past several years. The study began with 20 patients and 88 samples, and ultimately compared and reviewed data from 17 patients and 64 samples. Through this, the researchers reassessed the reliability of conventional PGT-A results and evaluated whether the non-invasive testing method could serve as a practical alternative in clinical settings.

The results showed that there was not complete concordance between PGT-A and ni-PGT in determining chromosomal abnormalities. In some cases, embryos judged as aneuploid (chromosomally abnormal) by PGT-A were found to be euploid (chromosomally normal) by ni-PGT, suggesting that caution is needed when interpreting conventional PGT-A results.

Dr. Lee Chaesik stated, "This study is a meaningful achievement that demonstrates the potential of non-invasive genetic diagnostic technology, which can ensure accuracy while minimizing damage to embryos. We will continue to expand clinical research on non-invasive diagnostic methods to improve pregnancy success rates for couples experiencing infertility."

The American Society for Reproductive Medicine (ASRM) hosts the world's largest academic conference in the field, attended annually by around 10,000 reproductive medicine experts from around the globe. It is a prestigious international stage where the latest research in reproductive medicine and embryonic genetics is presented.

Lee Sangchan, Director of Sehwa Hospital, commented, "This presentation proves that the Infertility Medicine Research Institute at Sehwa Hospital possesses internationally competitive research capabilities. We will lead a new paradigm in infertility treatment by expanding advanced reproductive medicine research and international academic exchanges."

Dr. Lee Chaesik, Sehwa Hospital.

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