Ildong Bioscience Publishes Research Paper on 'Body Fat Reduction Probiotics' in SCI Journal

[Asia Economy Reporter Myunghwan Lee] Ildong Bioscience announced on the 12th that a research paper confirming the body fat reduction effect of a probiotic strain has been published in an international academic journal.

The research paper was published in the SCI-level journal in the field of food nutrition, Molecular Nutrition & Food Research.

Previously, Ildong Bioscience conducted a joint study with Professor Younghoon Jung's research team from the Department of Food Engineering, College of Agriculture and Life Sciences, Kyungpook National University, to elucidate the body fat reduction effect of Bifidobacterium lactis IDCC 4301.

According to Ildong Bioscience, cell experiments using preadipocytes (3T3-L1) showed that the group of adipocytes treated with a specific concentration of IDCC 4301 lysate had a significantly reduced triglyceride content compared to the control group. They also explained that the expression of proteins involved in adipocyte differentiation and lipid synthesis was significantly suppressed.

In animal experiments conducted on laboratory mice, the group fed IDCC 4301 along with a high-fat diet for 12 weeks showed a significant reduction in body weight compared to the control group fed only a high-fat diet. The size of adipocytes also decreased. Additionally, the expression of genes involved in adipocyte differentiation and lipid synthesis was suppressed, while the expression of genes related to lipid breakdown increased.

Furthermore, blood analysis of the DCC 4301 intake group revealed a significant decrease in total cholesterol and LDL cholesterol. The expression of leptin, a hormone associated with obesity and one of the cytokines, was also found to be reduced.

An official from Ildong Bioscience stated, "Through this research, we confirmed the potential for expanding the commercialization of IDCC 4301," adding, "We plan to develop it as a functional raw material individually recognized by the Ministry of Food and Drug Safety related to body fat reduction after conducting human application tests."

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