Ajou University Research Team Develops New Material to Enhance Stem Cell Wound Healing Efficiency

Research Breakthrough Contributes to Advances in Regenerative Medicine

The research team at Ajou University has developed a new stem cell-based healing material that effectively treats wounds. The material accelerates the healing process and demonstrates high efficiency and safety, leading to evaluations that it presents a new paradigm in stem cell therapy.

The research team at Ajou University developed a wound healing strategy combining stem cell injection and SP1+Cx-SIS dressing, and demonstrated its efficacy through experiments (research image). Ajou University

On September 23, Ajou University announced that the research team led by Professor Kim Moonseok (Department of Applied Chemistry, Graduate School of Molecular Science and Technology) and Professor Choi Sangdon (College of Advanced Bio-Convergence, Graduate School of Molecular Science and Technology) has developed a "stem cell-induced wound healing dressing formulation."

Stem cells are the foundational cells that form the body's tissues and organs, and they are widely used in the treatment of various intractable diseases.

However, a key issue with conventional methods has been that stem cells harvested and cultured externally do not stably settle at the wound site.

To address this, the Ajou University research team combined stem cells with a dressing agent to ensure that the transplanted stem cells are precisely positioned at the wound site. In this process, they utilized "SP1 peptide," a bioactive substance belonging to the neuropeptide family.

The SP1 peptide is a new material discovered by the Ajou University team using artificial intelligence technology and has been patented in both Korea and the United States.

In actual animal experiments, the stem cells remained at the wound site for a longer period, and the recovery rate was accelerated. Side effects such as inflammatory responses were also reduced.

Professor Kim Moonseok stated, "Through this research, we have proposed a new treatment paradigm that simultaneously enhances the efficiency and safety of targeted stem cell therapies."

Professor Choi Sangdon added, "Since this can be applied to clinically challenging conditions such as intractable wounds, we expect it to become a next-generation wound healing agent in the field of tissue regenerative engineering."

Meanwhile, these results have been published online in the international journal "Journal of Controlled Release," which specializes in drug efficacy enhancement.

This content was produced with the assistance of AI translation services.