Chong Kun Dang "Diabetes New Drug 'Duvie' Shows Excellent Metabolic Syndrome Improvement Effects"

[Asia Economy Reporter Cho Hyun-ui] Large-scale clinical results of Chong Kun Dang's new diabetes drug 'Duvie' showed an 11.9% decrease in the proportion of patients with metabolic syndrome. Duvie is the 20th new drug developed domestically by Chong Kun Dang and is a thiazolidinedione class type 2 diabetes treatment.

On the 25th, Chong Kun Dang announced that a paper proving this effect of Duvie was published in the SCI-level international journal Diabetes, Obesity and Metabolism.

This paper is the result of a large-scale clinical trial conducted from January 28, 2015, to October 31, 2018, at 27 institutions in Korea, involving 247 subjects, directly comparing Duvie and the DPP-4 inhibitor sitagliptin.

Chong Kun Dang divided type 2 diabetes patients with metabolic syndrome into two groups and administered metformin with Duvie and metformin with sitagliptin respectively for 24 weeks, then examined the blood sugar lowering effect and the proportion of patients with metabolic syndrome.

According to the study results, the primary endpoint, blood sugar lowering effect, showed no significant difference between the two groups. Both the reduction rate of glycated hemoglobin and the achievement rate of targets showed similar results.

For the secondary endpoint, the proportion of patients with metabolic syndrome decreased by 4.8% in the sitagliptin group, whereas it decreased by 11.9% in the Duvie group, demonstrating the superior metabolic syndrome improvement effect of Duvie. Blood lipid levels such as triglycerides, high-density cholesterol, free fatty acids, and adiponectin were also significantly improved in the Duvie group.

Neither group showed serious side effects, and the incidence rates of adverse reactions such as weight gain and facial edema showed no statistical difference between the two groups.

A Chong Kun Dang official said, “As the number of diabetes patients with metabolic syndrome is increasing recently, the significance of this study result is even greater,” and added, “Duvie will be a new option for diabetes treatment and greatly help in preventing complications in patients.”

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