Korean Medicine Institute Begins Phase 3 Clinical Trial of Herbal Cough and Expectorant Medicine
[Asia Economy Reporter Junho Hwang] Clinical trials involving patients for GHX02, a cough suppressant and expectorant using herbal medicine formulations, are set to begin.
According to the Korea Institute of Oriental Medicine on the 7th, a Phase 3 clinical trial for acute bronchitis patients using 'GHX02' will commence.
GHX02 is an acute bronchitis treatment developed through a project selected by the Korea Institute of Oriental Medicine's open innovation R&D program targeting industry-academia-research related to Korean medicine. The Korea Institute of Oriental Medicine, Daejeon University Korean Medicine Hospital, and Korea New Drug Co., Ltd. jointly developed it.
In this Phase 3 clinical trial, a large-scale patient comparison study with existing treatments will be conducted. Based on the trial results, further research for the commercialization of 'GHX02' will also be pursued.
The Korea Institute of Oriental Medicine confirmed through non-clinical efficacy tests that this treatment suppresses the production of inflammatory mediators such as leukotrienes and inflammatory cytokines that cause respiratory diseases. In the Phase 2 clinical trial to verify efficacy, safety, and appropriate dosage, it was found to improve symptoms in patients with acute and chronic bronchitis exacerbations. Experiments on human-derived bronchial epithelial cells also revealed the mechanism of action by reducing the activity of nuclear factor kappa B (NF-kB), which is involved in bronchial inflammation, thereby suppressing inflammation.
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Dr. Sungwook Chae of the Global Research Cooperation Team stated, "Herbal medicine formulations, which are mixtures of various components, act simultaneously on multiple targets, making them effective for chronic and intractable diseases with fewer side effects, thus favorable for long-term use." He added, "We will continue to expand the scope of research and conduct evidence-building studies on the therapeutic effects of various herbal medicine formulations."
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