Jeonnam National University Research Team Discovers Predictors of Immunogenicity in Lung Cancer

Infographic of lung cancer immunogenicity predictors by Professor Jaeho Cho's team at Chonnam National University. Photo by Chonnam National University.

[Asia Economy Honam Reporting Headquarters Reporter Cho Hyung-joo] A research team at Chonnam National University has discovered an immunogenicity predictor for lung cancer.

According to Chonnam National University on the 6th, Professor Cho Jae-ho's team (Department of Medicine MRC) at the College of Medicine, in collaboration with Professors Yang Deok-hwan (Department of Hematology and Oncology), Song Sang-yoon (Department of Thoracic Surgery), and Oh In-jae (Department of Pulmonology), identified a specific cluster of CD8 T cells in the blood and tissues of non-small cell lung cancer patients and demonstrated that the differentiation specificity of these cells is closely correlated with lung cancer immunogenicity.

The research team compared the phenotypic and gene expression characteristics of TEMRA cells, known as a subset of CD8 T cell clusters, in the blood and tissues of non-small cell lung cancer patients and discovered differences in the complexity and differentiation processes of these cell clusters.

They also identified factors determining the differentiation of these cells and demonstrated that these characteristics are linked to cancer antigen immunogenicity.

Cancer antigen immunogenicity is considered an important predictor of response before and after anticancer immunotherapy.

Professor Cho Jae-ho stated, “Through this research, we can better understand the interaction between cancer and immune cells and contribute to the development of predictors for cancer immunotherapy response using immune checkpoint inhibitors.”

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